You go through your problems and then a dear friend accidentally kills a prof, getting his friends to cover up to protect him. He drowns in depression until he meets the widow in a hospital and cares for her through volunteer work.
The friends are not that friendly to each other as one (a divorcee violent with his gf) is bent on make his pal's marriage crumble hoping to grab the wife, whom he feels should be his. He leverages an old acquaintance, who has her own agenda (she has cancer and wants to score the guy before she dies).
The marriage does fall apart, but no one wins.
Everyone pays and is left to pay for their sins in a Buddhist weltanschauung that permeates the whole series.